| Disney Television Studios | television production company, division | — | May 15, 2019 |
| DLA Piper | law firm | New York City | 2005 |
| Dolby | business, enterprise, public company | San Francisco | 1965 |
| Dollar General | variety store chain, discount store, business, retail chain, enterprise, public company | Goodlettsville | 1939 |
| Dominican University | private not-for-profit educational institution, university, Catholic university | — | 1901 |
| Dominion Energy | business, enterprise, public company | Richmond | 1983 |
| DoubleTree by Hilton | hotel brand, hotel chain, business, enterprise | McLean | 1969 |
| Dover Publications | book publisher, music publisher, public company | New York, Mineola | 1941 |
| Dow Inc. | enterprise, public company | Midland | January 1, 2019 |
| Dow Jones & Company | business, enterprise | New York City | 1882 |
| Drag City | independent record label | Chicago | 1990 |
| DreamWorks | film production company, film distributor | Universal City | October 12, 1994 |
| DreamWorks Animation | animation studio, film production company, film studio, public company | Glendale | 1994 |
| Drexel University | research university, private not-for-profit educational institution | — | 1891 |
| Dumbarton Oaks | research library, mansion, research institute, museum, academic publisher | — | 1940 |
| Dun & Bradstreet | business, subsidiary company, enterprise | — | 1841 |
| Dunkin' Brands | business, enterprise, public company | Canton | 1950 |
| Duquesne University | private not-for-profit educational institution, Catholic university | — | 1878 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| DYMO Corporation | business | Berkeley | 1958 |
| Dynamite Entertainment | comics publishing company, production company, publishing house, imprint | Mount Laurel | 2004 |
| E-mu Systems | business, musical instrument manufacturing company | Scotts Valley | 1971 |
| E-ZPass | business | Wilmington | 1987 |
| E. Remington & Sons | business | United States | 1816 |
| EA Sports | business | Burnaby | 1991 |
| Eagle | car brand, automobile manufacturer | — | 1987 |
| Eagle Crest Resort | unincorporated community, hotel, census-designated place in the United States | — | 1985 |
| EarthLink | business, enterprise, public company | Atlanta, Pasadena, Atwater Village | 1994 |
| East Carolina University | public educational institution of the United States, public research university | Greenville | March 8, 1907 |
| Eastern Air Lines | airline | Miami | 1926 |
| Eastern Airlines, LLC | airline | Greensboro | 2010 |
| Eastern Kentucky University | public educational institution of the United States, university | — | 1874 |
| Eastern Oregon University | public educational institution of the United States, public university | — | 1929 |
| Eastman Chemical Company | business, enterprise, public company | Kingsport | 1920 |
| Eataly | business, retail chain, enterprise | Monticello d'Alba | 2010 |
| Eaton Corporation | business, enterprise, public company | Cleveland | 1911 |
| EC Comics | comics publishing company, book publisher | New York City | 1944 |
| Eclipse Comics | comics publishing company, book publisher, business | Forestville, Staten Island | 1977 |
| Ecolab | business, public company | Saint Paul | 1923 |
| Edelman | public relations agency, consulting company, business | New York City | 1952 |
| Edition Peters | group of companies, music publisher | Frankfurt | December 1, 1800 |
| Edmodo | skill, website, business | San Mateo | September 1, 2008 |
| El Tovar Hotel | hotel | — | 1903 |
| Electro-Motive Diesel | brand, business | La Grange | 1922 |
| Elliott Investment Management | business, company | New York City | 1977 |
| Elon University | university | — | 1889 |
| Elsevier | book publisher, academic publisher | Amsterdam | 1880 |
| Emerson College | private not-for-profit educational institution, university | Boston | 1880 |