| F. W. Woolworth Company | business, public company | New York City | 1878 |
| FactSet | business, public company | Norwalk | 1978 |
| Fairfax County Public Schools | school division of Virginia | — | 1870 |
| Fakku | pornography website, video game publisher, manga publisher | Portland | 2006 |
| Falcon Entertainment | pornographic film distributor, pornography website, pornographic film studio | San Francisco | 1971 |
| Famous Players-Lasky Corporation | film studio | Los Angeles | April 1, 1927 |
| Fandango | online film database, website, business | Los Angeles | 2000 |
| Fantagraphics Books | comics publishing company, book publisher | Seattle | 1976 |
| Faraday Future | automobile manufacturer | Gardena | 2014 |
| Farmers Insurance Group | insurance company, business | Wilshire Boulevard, Los Angeles | 1928 |
| Fatburger | restaurant chain | Santa Monica, Los Angeles | 1952 |
| Faulkner University | church college, private not-for-profit educational institution, university | — | 1942 |
| Fawcett Comics | publishing house | New York City | 1939 |
| Fayetteville State University | historically black college or university, public educational institution of the United States, school, university | Fayetteville | 1867 |
| Feastables | business, company | Chicago | April 2021 |
| Federal Deposit Insurance Corporation | independent agency of the United States government, state-owned enterprise of the United States | Washington, D.C. | June 16, 1933 |
| Federal Law Enforcement Training Center | United States federal agency, police academy, school | Glynco, Georgia | 1970 |
| Federal Reserve Bank of Boston | organization, Federal Reserve Bank | Boston | October 1914 |
| Federal Reserve Bank of Kansas City | organization, Federal Reserve Bank | 1 Memorial Drive, 925 Grand | — |
| Federal Reserve Bank of Philadelphia | organization, Federal Reserve Bank | — | 1914 |
| Feedly | news aggregator | — | 2008 |
| FEI Company | business, enterprise, public company | Hillsboro | 1971 |
| Fender Musical Instruments Corporation | business, musical instrument manufacturing company | Nabari Station | 1946 |
| Fenty Beauty | brand, business | 425 Market Street | September 8, 2018 |
| Fenway Sports Group | business, enterprise | Boston | 2001 |
| Fidelity Investments | business, enterprise | Boston | 1946 |
| Film Roman | animation studio, film production company | Burbank | October 26, 1984 |
| FilmEngine | film production company | Beverly Hills | 2001 |
| Fine Air | cargo airline | Miami | 1989 |
| Firaxis Games | video game developer | Sparks | 1996 |
| Firebase | service on Internet, software framework, business | San Francisco | 2010 |
| Firefly Aerospace | launch service provider, business | Cedar Park | 2014 |
| Firehouse Subs | business | — | 1994 |
| First Citizens BancShares | bank holding company, business, public company | Raleigh | August 7, 1986 |
| First Look Media | news agency | New York City | 2013 |
| First National Pictures | film production company | United States | 1917 |
| First Solar | business, enterprise, public company | Tempe | 1999 |
| FirstEnergy | business, public company | Akron | 1997 |
| Fiserv | business, enterprise, public company | Brookfield | 1984 |
| Fisher-Price | brand, business, subsidiary company | New York | June 19, 1930 |
| Fisk University | historically black college or university, private not-for-profit educational institution, school, private university | — | 1866 |
| Flagship Studios | video game developer | San Francisco | 2003 |
| Fleshlight | artificial vagina, brand, online shop | Austin | 1998 |
| Florida East Coast Railway | transport company | — | 1899 |
| Fluke Corporation | business, enterprise | Everett | 1948 |
| Fluor Corporation | business, public company | Irving | 1890 |
| FMC Corporation | business, enterprise, public company | BNY Mellon Center | 1883 |
| FMC Technologies | business, public company | Houston | 2000 |
| Fodera | business, musical instrument manufacturing company | New York City | 1983 |
| Fontainebleau Las Vegas | skyscraper, casino, hotel, resort | — | 2023 |
| Fontainebleau Miami Beach | convention center, hotel, landmark, resort | Miami Beach | 1954 |
| Ford Foundation | production company, nonprofit organization, collection | Ford Foundation Center for Social Justice | 1936 |
| Ford Motor Company | holding company, organization, business, automobile manufacturer, public company | Dearborn | June 16, 1903 |
| Fort Benning | unincorporated community, educational institution, garrison | — | 1918 |
| Fort Bliss | military base, Training Center of the German Airforce, census-designated place in the United States | — | 1849 |
| Fortinet | business, public company | Sunnyvale | 2000 |
| Fortress Investment Group | public company | 1345 Avenue of the Americas | 1998 |
| Fox 2000 Pictures | business | Century City | January 7, 1994 |
| Fox Atomic | business | — | 2006 |
| Fox Corporation | media company, holding company, public company | New York City | 2019 |
| Fox Crime | television production company, television channel | — | 2005 |
| Fox Film Corporation | production company, film production company, film studio | Hollywood | 1915 |
| Fox Kids | television production company, television channel, specialty channel | United States | September 8, 1990 |
| Fox Networks Group | television production company, business | Los Angeles | 1993 |
| Fox News | specialty channel, cable news in the United States | New York City | October 7, 1996 |
| Fox Sports Networks | television production company, television station, specialty channel | Los Angeles | 1996 |
| Fox Television Stations | business, subsidiary company | New York City | 1986 |
| Framework | enterprise | Burlingame | December 2019 |
| Framingham State University | public educational institution of the United States, university | — | 1839 |
| Franklin Templeton Investments | business, enterprise, public company | San Mateo | 1947 |
| Free Library of Philadelphia | nonprofit organization, library network, public library | Philadelphia | 1891 |
| Freeport-McMoRan | business, enterprise, public company | Phoenix | 1912 |
| Freightliner Trucks | truck manufacturer, trademark | Portland | 1939 |
| Frigidaire | business, subsidiary company, enterprise | Charlotte | 1918 |
| Frogdesign | organization, business | San Francisco | 1969 |
| Fruit of the Loom | business | Bowling Green | 1851 |
| Fulbright Scholarship | scholarship, government program, educational institution | — | 1946 |
| Full Sail University | private for-profit educational institution, university | — | 1972 |
| Funny or Die | business | San Mateo | April 12, 2007 |
| Future Shop | business | Burnaby | 1982 |
| FX | television production company, cable channel | Texas, New York City, Pico Boulevard | June 1, 1994 |