| Waco | business | Troy | 1919 |
| Wagner College | college, private not-for-profit educational institution | — | 1883 |
| Walgreens | pharmacy chain, public company | Deerfield | 1901 |
| Walker Art Center | art gallery, nonprofit organization, art museum, movie theater | Hennepin Avenue | 1927 |
| Walsh School of Foreign Service | school of international relations, college | — | 1919 |
| Walt Disney Animation Studios | animation studio, film production company | Burbank | October 16, 1923 |
| Walt Disney Imagineering | business | Glendale | 1952 |
| Walt Disney Studios | film studio | Burbank | 1923 |
| Walt Disney Studios | corporate headquarters, film studio | Burbank | February 27, 1940 |
| Walters Art Museum | art museum, publishing house | Baltimore | 1934 |
| Waltham Watch Company | business | Waltham, Amsterdam | 1850 |
| Wargaming Seattle | video game developer | Redmond | — |
| Warner Bros. Cartoons | business | Burbank, Los Angeles | November 10, 1926 |
| Warner Bros. Discovery | production company, business, enterprise, conglomerate, public company | New York City | April 8, 2022 |
| Warner Bros. Entertainment | film production company, entertainment company | Burbank | April 4, 1923 |
| Warner Bros. Records Inc. | record company, business, subsidiary company | New York City | March 19, 1958 |
| Warner Bros. Studios, Burbank | film studio | Burbank | 1926 |
| Warner Bros.-Seven Arts | production company, entertainment company | Burbank | July 15, 1967 |
| Warner Communications | entertainment company, conglomerate | New York City | February 1972 |
| Warner Independent Pictures | film production company, film distributor | Burbank | August 2003 |
| Warrior Sports | business, enterprise | Warren | 1992 |
| Washburn Guitars | trademark, musical instrument manufacturing company, subsidiary company | Chicago | 1883 |
| Washington University in St. Louis | private not-for-profit educational institution, private university | St. Louis, St. Louis County | 1853 |
| Waste Management, Inc | business, public company | Houston | 1968 |
| Watch Tower Bible and Tract Society of Pennsylvania | nonprofit organization, real estate company, publishing house | Warwick | 1884 |
| Waterman | business | Paris | 1883 |
| Waters Corporation | business, enterprise | Milford | 1958 |
| WayForward Technologies | video game publisher, video game developer | Valencia | 1990 |
| Wayne State University | public educational institution of the United States, public research university | Detroit | 1868 |
| WB Games Boston | video game developer | Westwood | 1994 |
| WCBS-TV | production company, television station | New York City | July 1, 1941 |
| Webster Bank | bank, business, public company | Stamford | 1935 |
| Weill Cornell Medicine | private not-for-profit educational institution, medical facility, medical school | — | April 14, 1898 |
| Weitek | business | San Jose | 1981 |
| Wellesley College | private not-for-profit educational institution, women's college, university | — | 1870 |
| West Chester University of Pennsylvania | public educational institution of the United States, university | — | 1871 |
| Western Carolina University | public educational institution of the United States, university | — | 1889 |
| Western Design Center | business | Mesa | 1978 |
| Western Electric | organization, business, enterprise | New York City | 1869 |
| Western Global Airlines | airline | Estero | March 6, 2013 |
| Western Michigan University | public educational institution of the United States, open-access publisher, public university | — | 1903 |
| Western Pacific Railroad | business, transport company | San Francisco | 1916 |
| Western Union | business, financial institution, public company | Denver | April 1856 |
| Westinghouse Electric Company | business, enterprise | Cranberry Township | 1999 |
| Westwood Studios | video game developer, business | Las Vegas | 1992 |
| Wexner Center for the Arts | art gallery, art museum, movie theater | — | 1989 |
| Weyerhaeuser | business, enterprise, public company | Seattle, Federal Way | 1900 |
| Whataburger | fast food restaurant chain | — | 1950 |
| Wheaton College | liberal arts college, church college, Colleges That Change Lives, private not-for-profit educational institution | — | 1860 |
| Whisky a Go Go | nightclub, music venue | — | January 16, 1964 |
| White Sands Test Facility | rocket engine test facility | — | 1963 |
| Whole Foods Market | gourmet supermarket chain, health food store chain, enterprise, public company | Austin | September 20, 1980 |
| WHOOP | business | Boston | — |
| Wicked Pictures | pornography company, pornographic film studio | Canoga Park | 1993 |
| Wildfire Games | video game developer, enterprise | United States | 2002 |
| Wiley | book publisher, publishing house, educational publishing company, open-access publisher, public company, academic publisher | Hoboken | 1807 |
| William B. Eerdmans Publishing Company | book publisher, business | Grand Rapids | 1911 |
| William Morrow | book publisher, imprint | New York City | 1926 |
| Williams Companies | energy company, public company | Tulsa | 1908 |
| Willys | business, automobile manufacturer | Toledo | 1908 |
| Wilson Sporting Goods | sporting goods manufacturer, organization, business | Chicago | 1913 |
| Windstar Cruises | private company limited by shares, cruise line | Seattle | 1984 |
| Wingstop | fast food restaurant chain, business, public company | Dallas | 1994 |
| Winona State University | public educational institution of the United States, university | — | 1858 |
| WiTricity | business | Watertown | 2007 |
| WME Group | record label, business, talent agency, public company | Beverly Hills | 1898 |
| Worcester Polytechnic Institute | private not-for-profit educational institution, university | — | 1865 |
| WordPress.com | domain name registrar, content management system, website builder, nonprofit organization, business, web hosting service, Fediverse app | San Francisco | 2005 |
| World Airways | airline | Peachtree City | March 29, 1948 |
| World Championship Wrestling | privately held company, business, subsidiary company | Atlanta | October 11, 1988 |
| World Wrestling Council | business, professional wrestling promotion | Puerto Rico | 1973 |
| WSP Global | business, public company | Montreal | 1959 |
| WW International | business, enterprise, public company | New York City | 1963 |
| WWE | business, professional wrestling promotion, public company | Stamford | 1952 |
| Wynn Resorts | organization, business, enterprise, public company | Las Vegas | 2002 |