| E-mu Systems | business, musical instrument manufacturing company | Scotts Valley | 1971 |
| E-ZPass | business | Wilmington | 1987 |
| E. Remington & Sons | business | United States | 1816 |
| EA Sports | business | Burnaby | 1991 |
| Eagle | car brand, automobile manufacturer | — | 1987 |
| Eagle Crest Resort | unincorporated community, hotel, census-designated place in the United States | — | 1985 |
| EarthLink | business, enterprise, public company | Atlanta, Pasadena, Atwater Village | 1994 |
| East Carolina University | public educational institution of the United States, public research university | Greenville | March 8, 1907 |
| Eastern Air Lines | airline | Miami | 1926 |
| Eastern Airlines, LLC | airline | Greensboro | 2010 |
| Eastern Kentucky University | public educational institution of the United States, university | — | 1874 |
| Eastern Oregon University | public educational institution of the United States, public university | — | 1929 |
| Eastman Chemical Company | business, enterprise, public company | Kingsport | 1920 |
| Eataly | business, retail chain, enterprise | Monticello d'Alba | 2010 |
| Eaton Corporation | business, enterprise, public company | Cleveland | 1911 |
| EC Comics | comics publishing company, book publisher | New York City | 1944 |
| Eclipse Comics | comics publishing company, book publisher, business | Forestville, Staten Island | 1977 |
| Ecolab | business, public company | Saint Paul | 1923 |
| Edelman | public relations agency, consulting company, business | New York City | 1952 |
| Edition Peters | group of companies, music publisher | Frankfurt | December 1, 1800 |
| Edmodo | skill, website, business | San Mateo | September 1, 2008 |
| El Tovar Hotel | hotel | — | 1903 |
| Electro-Motive Diesel | brand, business | La Grange | 1922 |
| Elliott Investment Management | business, company | New York City | 1977 |
| Elon University | university | — | 1889 |
| Elsevier | book publisher, academic publisher | Amsterdam | 1880 |
| Emerson College | private not-for-profit educational institution, university | Boston | 1880 |
| Encyclopædia Britannica Inc. | book publisher, business | Chicago | 1768 |
| Enstrom Helicopter Corporation | business | Menominee | 1959 |
| Enterprise Products | business, public company | Houston | 1968 |
| Envoy Air | airline | Fort Worth | 1984 |
| Epcot | theme park | — | October 1, 1982 |
| Epicor | business, enterprise | Austin, Irvine | 1972 |
| Epiphone | brand, business | Nashville | 1873 |
| Esalen Institute | retreat center, 501(c)(3) organization, educational institution | Slates Hot Springs | 1962 |
| Esso | brand, gas station chain | Irving | 1911 |
| Estée Lauder Companies | business, enterprise, public company | Neuilly-sur-Seine, New York City | 1946 |
| Eurasia Group | consulting company, business | New York City | 1998 |
| Euronet Worldwide | business, public company | Leawood | 1994 |
| Evergreen State College | liberal arts college, Colleges That Change Lives, public educational institution of the United States | — | 1967 |
| Everts Air | airline | Fairbanks | 1977 |
| Evil Angel | pornographic film studio | Van Nuys | 1989 |
| Evolve | business | Philadelphia | 2009 |
| Exelon | holding company, business, enterprise, public company | Chicago | 2000 |
| Exidy | business | Sunnyvale | 1974 |
| Expedia Group | business, enterprise, public company | Seattle | October 22, 1996 |
| Extreme Championship Wrestling | media franchise, business | Philadelphia | April 25, 1992 |
| Exxon | oil company, business, gas station chain, public company | Las Colinas | January 1, 1973 |
| ExxonMobil | oil company, multinational corporation, business, gas station chain, enterprise, public company | Spring | August 5, 1882 |