| Valiant Comics | comics publishing company, business | New York City | 1989 |
| Valve Corporation | computer manufacturer, software company, video game publisher, video game developer | Bellevue | 1996 |
| Valvoline | public company | Lexington | September 6, 1866 |
| Vassar College | private not-for-profit educational institution, liberal arts college in the United States | — | 1861 |
| VCA Pictures | pornographic film distributor, pornographic film studio | Culver City | — |
| Venmo | online service, website, business | New York City | 2009 |
| Vertex Pharmaceuticals | pharmaceutical company, organization, business, public company | Boston | 1989 |
| Vertiv | multinational corporation, business, enterprise, public company | Westerville | 1965 |
| Viacom | business, enterprise, public company | One Astor Plaza | December 31, 2005 |
| Viagogo | business, ticket sales service, ticket reseller | London | 2006 |
| Viasat | telecommunications company, business, public company | Carlsbad | 1986 |
| Vic Firth Company | business, musical instrument manufacturing company | Boston | 1963 |
| Vicarious | privately held company | San Francisco | 2010 |
| Vice Media Group | business | Williamsburg | 1994 |
| Vici Properties | casino, real estate company, public company | New York City | October 6, 2017 |
| Vicks | brand, business | Cincinnati | 1890 |
| Victoria's Secret Fashion Show | fashion show, recurring event, business | — | 1995 |
| Viking Press | book publisher, publishing house, imprint | New York City | 1925 |
| Village Roadshow Pictures | business, enterprise | Los Angeles | 1986 |
| Virginia Museum of Fine Arts | art museum, publishing house, museum | — | March 27, 1934 |
| Vision Airlines | airline | Las Vegas | 1994 |
| Visteon | business, enterprise, public company | Van Buren Charter Township | 2000 |
| Vivendi Games | video game developer, business | Los Angeles | February 21, 1996 |
| Vivid Entertainment | pornographic film distributor, pornographic film studio | Los Angeles | 1984 |
| VLF Automotive | automobile manufacturer | Rochester | 2015 |
| Volcom | business, public company | Costa Mesa | 1991 |
| Volition | video game developer | Champaign | November 1996 |
| Vonage | business, public company | Holmdel Township | 2001 |
| Vox Media | media company, organization | New York, New York City, Washington, D.C. | 2011 |
| Vyond | software company, privately held company, business | San Mateo | November 1, 2007 |