| Y Combinator | educational institution, startup accelerator, business, educational program, enterprise | Mountain View | March 2005 |
| Yacht Club Games | video game developer | Valencia | 2011 |
| Yahoo Inc. | division, business, new media, company | Sunnyvale, New York City | 2006 |
| Yale College | college | — | 1701 |
| Yale Law School | law school, academic publisher | New Haven | 1824 |
| Yale School of Drama | drama school | — | 1924 |
| Yale University | production company, colonial colleges, research university, private not-for-profit educational institution, private university, academic publisher | New Haven | 1701 |
| Yen Press, LLC | comics publishing company, book publisher, audiobook publisher, business | New York City | 2006 |
| YIVO Institute for Jewish Research | Jewish organization, nonprofit organization, publishing house, research institute | New York City | 1925 |
| Youngstown State University | public educational institution of the United States, university | — | 1908 |
| Yuengling | brewery | Pottsville | 1829 |
| Yum! Brands | corporation, group of companies, public company | Louisville | 1997 |