| Weyerhaeuser | business, enterprise, public company | Seattle, Federal Way | 1900 |
| Whataburger | fast food restaurant chain | — | 1950 |
| Wheaton College | liberal arts college, church college, Colleges That Change Lives, private not-for-profit educational institution | — | 1860 |
| Whisky a Go Go | nightclub, music venue | — | January 16, 1964 |
| White Sands Test Facility | rocket engine test facility | — | 1963 |
| Whole Foods Market | gourmet supermarket chain, health food store chain, enterprise, public company | Austin | September 20, 1980 |
| WHOOP | business | Boston | — |
| Wicked Pictures | pornography company, pornographic film studio | Canoga Park | 1993 |
| Wildfire Games | video game developer, enterprise | United States | 2002 |
| Wiley | book publisher, publishing house, educational publishing company, open-access publisher, public company, academic publisher | Hoboken | 1807 |
| William B. Eerdmans Publishing Company | book publisher, business | Grand Rapids | 1911 |
| William Morrow | book publisher, imprint | New York City | 1926 |
| Williams Companies | energy company, public company | Tulsa | 1908 |
| Willys | business, automobile manufacturer | Toledo | 1908 |
| Wilson Sporting Goods | sporting goods manufacturer, organization, business | Chicago | 1913 |
| Windstar Cruises | private company limited by shares, cruise line | Seattle | 1984 |
| Wingstop | fast food restaurant chain, business, public company | Dallas | 1994 |
| Winona State University | public educational institution of the United States, university | — | 1858 |
| WiTricity | business | Watertown | 2007 |
| WME Group | record label, business, talent agency, public company | Beverly Hills | 1898 |
| Worcester Polytechnic Institute | private not-for-profit educational institution, university | — | 1865 |
| WordPress.com | domain name registrar, content management system, website builder, nonprofit organization, business, web hosting service, Fediverse app | San Francisco | 2005 |
| World Airways | airline | Peachtree City | March 29, 1948 |
| World Championship Wrestling | privately held company, business, subsidiary company | Atlanta | October 11, 1988 |
| World Wrestling Council | business, professional wrestling promotion | Puerto Rico | 1973 |
| WSP Global | business, public company | Montreal | 1959 |
| WW International | business, enterprise, public company | New York City | 1963 |
| WWE | business, professional wrestling promotion, public company | Stamford | 1952 |
| Wynn Resorts | organization, business, enterprise, public company | Las Vegas | 2002 |
| XBIZ | business, online magazine | Los Angeles | 1998 |
| Xcel Energy | business, public company | Minneapolis | 1998 |
| XFX | business | Ontario, California | 1989 |
| Xilinx | business, enterprise | San Jose | 1984 |
| Ximian | business, enterprise | Boston | October 19, 1999 |
| XPO, Inc. | logistics company, business, enterprise, public company | Greenwich | 1987 |
| XYZ Films | film studio | Los Angeles | 2008 |
| Y Combinator | educational institution, startup accelerator, business, educational program, enterprise | Mountain View | March 2005 |
| Yacht Club Games | video game developer | Valencia | 2011 |
| Yahoo Inc. | division, business, new media, company | Sunnyvale, New York City | 2006 |
| Yale College | college | — | 1701 |
| Yale Law School | law school, academic publisher | New Haven | 1824 |
| Yale School of Drama | drama school | — | 1924 |
| Yale University | production company, colonial colleges, research university, private not-for-profit educational institution, private university, academic publisher | New Haven | 1701 |
| Yen Press, LLC | comics publishing company, book publisher, audiobook publisher, business | New York City | 2006 |
| YIVO Institute for Jewish Research | Jewish organization, nonprofit organization, publishing house, research institute | New York City | 1925 |
| Youngstown State University | public educational institution of the United States, university | — | 1908 |
| Yuengling | brewery | Pottsville | 1829 |
| Yum! Brands | corporation, group of companies, public company | Louisville | 1997 |