| Republic Pictures | Poverty Row | Hollywood | 1935 |
| Respawn Entertainment | video game developer | Sherman Oaks, Los Angeles | 2010 |
| Revlon | business, enterprise, public company | New York City | 1932 |
| Revolution Studios | business | Los Angeles | 2000 |
| Rhino Entertainment Company | production company, record company, subsidiary company | Los Angeles | 1998 |
| Richard Childress Racing | auto racing team, business | — | 1969 |
| Rickenbacker | business, musical instrument manufacturing company | Santa Ana | 1931 |
| Rickenbacker | automobile manufacturer | Detroit | 1921 |
| Rio All-Suite Hotel and Casino | casino, hotel | — | January 15, 1990 |
| Riseup | internet service provider, mailbox provider, collective, worker cooperative, charitable organization | Seattle | 1999 |
| Rivian Automotive | business, enterprise, automobile manufacturer, public company | Detroit | June 2009 |
| Riviera Hotel and Casino | skyscraper, casino, hotel | — | 1955 |
| RJR Nabisco | business | Cobb County, Winston-Salem, New York City | April 25, 1986 |
| Rocket Lab | launch service provider, aerospace manufacturer | Long Beach | June 29, 2006 |
| Rockhurst University | private not-for-profit educational institution, university | Clayton | 1910 |
| Rockstar Games | video game publisher | New York City | December 1998 |
| Rockwell International | conglomerate, public company | United States | February 1973 |
| Rogers Locomotive and Machine Works | business | — | 1832 |
| Rogue | film production company | Universal City | 1997 |
| Rohm and Haas | business, enterprise | Philadelphia | September 1, 1909 |
| Roku, Inc. | business, enterprise, public company | Los Gatos | October 2002 |
| Roosevelt University | private not-for-profit educational institution, university | — | April 24, 1945 |
| Rooster Teeth | YouTube channel, film production company | Austin, Los Angeles, Flower Mound | April 1, 2003 |
| Ross Dress for Less | department store chain, enterprise, public company | Dublin | 1954 |
| Rotten Tomatoes | online film database, review site, business | San Francisco | August 19, 1998 |
| Rough Draft Studios | business, enterprise | Glendale | 1990 |
| Rowan University | public educational institution of the United States, public university | Glassboro | 1923 |
| Roxy Theatre | nightclub, music venue | — | September 23, 1973 |
| Royal Hawaiian Hotel | hotel, hotel building | — | 1927 |
| RSA | business, enterprise | Bedford | 1986 |
| RTX | defense contractor, business, public company | Arlington County | April 3, 2020 |
| Rutgers University Press | university press | New Brunswick | 1936 |
| Rutherford B. Hayes Presidential Center | library | — | 1912 |
| Ryan Aeronautical | business | San Diego | 1934 |
| Ryder | business, retail chain, public company | Coral Gables | 1933 |
| S&P Global | business, enterprise, public company | Rockefeller Center, New York City | — |
| Saber Interactive | video game developer | Fort Lauderdale, Minsk, Sundsvall, Porto, Millburn, Community of Madrid, Saint Petersburg, Florida | 2001 |
| SAE International | engineering society, regulatory college, standards organization, business, company, academic publisher | Warrendale | 1905 |
| Safeway | supermarket chain, business, enterprise, public company | Pleasanton | 1915 |
| Sage Publishing | book publisher, open-access publisher, academic publisher | Thousand Oaks | 1965 |
| Sahara Las Vegas | skyscraper, hotel, casino hotel, music venue | — | 1952 |
| Saint Joseph Higher Secondary School | college | — | 1954 |
| Saint Peter's University | private not-for-profit educational institution, university | Jersey City | 1872 |
| Saint Vladimir's Orthodox Theological Seminary | private not-for-profit educational institution, seminary, university | — | 1938 |
| Saks Fifth Avenue | business | New York City | 1898 |
| Salesforce | software company, technology company, software developer, business, enterprise, public company | Salesforce Tower, San Francisco | February 3, 1999 |
| Sam Houston State University | public educational institution of the United States, university | — | 1879 |
| Sam's Club | supermarket chain | Bentonville | 1983 |