| Eurasia Group | New York City | 1998 |
| Euronet Worldwide | Leawood | 1994 |
| Evolve | Philadelphia | 2009 |
| Exelon | Chicago | 2000 |
| Exidy | Sunnyvale | 1974 |
| Expedia Group | Seattle | October 22, 1996 |
| Extreme Championship Wrestling | Philadelphia | April 25, 1992 |
| Exxon | Las Colinas | January 1, 1973 |
| ExxonMobil | Spring | August 5, 1882 |
| F. W. Woolworth Company | New York City | 1878 |
| FactSet | Norwalk | 1978 |
| Fandango | Los Angeles | 2000 |
| Farmers Insurance Group | Wilshire Boulevard, Los Angeles | 1928 |
| Feastables | Chicago | April 2021 |
| FEI Company | Hillsboro | 1971 |
| Fender Musical Instruments Corporation | Nabari Station | 1946 |
| Fenty Beauty | 425 Market Street | September 8, 2018 |
| Fenway Sports Group | Boston | 2001 |
| Fidelity Investments | Boston | 1946 |
| Firebase | San Francisco | 2010 |
| Firefly Aerospace | Cedar Park | 2014 |
| Firehouse Subs | — | 1994 |
| First Citizens BancShares | Raleigh | August 7, 1986 |
| First Solar | Tempe | 1999 |
| FirstEnergy | Akron | 1997 |
| Fiserv | Brookfield | 1984 |
| Fisher-Price | New York | June 19, 1930 |
| Fluke Corporation | Everett | 1948 |
| Fluor Corporation | Irving | 1890 |
| FMC Corporation | BNY Mellon Center | 1883 |
| FMC Technologies | Houston | 2000 |
| Fodera | New York City | 1983 |
| Ford Motor Company | Dearborn | June 16, 1903 |
| Fortinet | Sunnyvale | 2000 |
| Fox 2000 Pictures | Century City | January 7, 1994 |
| Fox Atomic | — | 2006 |
| Fox Networks Group | Los Angeles | 1993 |
| Fox Television Stations | New York City | 1986 |
| Franklin Templeton Investments | San Mateo | 1947 |
| Freeport-McMoRan | Phoenix | 1912 |
| Frigidaire | Charlotte | 1918 |
| Frogdesign | San Francisco | 1969 |
| Fruit of the Loom | Bowling Green | 1851 |
| Funny or Die | San Mateo | April 12, 2007 |
| Future Shop | Burnaby | 1982 |
| GameStop | Grapevine | August 20, 1980 |
| GameTek | North Miami Beach | 1987 |
| GE Aerospace | Evendale | April 15, 1892 |