| Booking Holdings | Norwalk | July 1997 |
| Booz Allen Hamilton | Tysons | 1914 |
| BorgWarner | Auburn Hills | 1880 |
| Boston Dynamics | Waltham | November 6, 1992 |
| Box | Redwood City | May 2009 |
| Broadcast Music, Inc. | Manhattan | 1939 |
| Broadcom | Irvine | August 1991 |
| Brocade Communications Systems | San Jose | 1995 |
| Brown & Williamson | Louisville | 1894 |
| Brown-Forman | Louisville | 1870 |
| Bucyrus International | South Milwaukee | 1880 |
| Budd Company | Philadelphia | 1912 |
| Budget Rent a Car | Chicago, Parsippany-Troy Hills | 1958 |
| Build-A-Bear Workshop | St. Louis | 1997 |
| Bunge Limited | Hamilton, White Plains | 1818 |
| Burger Chef | Indianapolis | 1954 |
| Burlington | Florence | 1972 |
| Burt's Bees | Durham | 1984 |
| Burton Snowboards | Burlington | 1977 |
| C. F. Martin & Company | Nazareth | 1833 |
| C. H. Robinson Worldwide | Eden Prairie | 1905 |
| Cabot Corporation | Boston | 1882 |
| Cadence Design Systems | San Jose | 1988 |
| Calico | San Francisco | September 18, 2013 |
| Cambridge Analytica | London | 2014 |
| Cannondale Bicycle Corporation | Bethel | 1971 |
| Canoo | Torrance | 2017 |
| Capital One | McLean | 1994 |
| Cardinal Health | Dublin | 1971 |
| CarMax | Goochland County | 1993 |
| Carrier Corporation | Farmington | June 26, 1915 |
| Cartercar | Pontiac | 1905 |
| Case Corporation | United States | 1842 |
| Case IH | Racine | 1984 |
| Caterpillar Inc. | Irving | 1925 |
| CBS Radio | New York City | 1928 |
| Celanese Corporation | Irving | 1999 |
| Celera Corporation | Rockville, Alameda | May 1998 |
| Century 21 Real Estate | Madison | 1971 |
| Cerberus Capital Management | New York City | 1992 |
| CH2M Hill | Meridian | 1946 |
| Champ Car | — | 1979 |
| Chaosium | Hayward, Albany | October 31, 1975 |
| Charlton Comics | Derby | 1945 |
| Charter Arms | Shelton | 1964 |
| Chemical Bank | Midland, New York City | 1954 |
| Chicago Board of Trade | Chicago | 1848 |
| Chicago Mercantile Exchange | Chicago | 1898 |