| United States Playing Card Company | Erlanger | 1867 |
| United States Rubber Company | Naugatuck | 1892 |
| United States Wrestling Association | Memphis | 1989 |
| United Technologies Corporation | Hartford | 1929 |
| USRobotics | Schaumburg | 1976 |
| Valiant Comics | New York City | 1989 |
| Venmo | New York City | 2009 |
| Vertex Pharmaceuticals | Boston | 1989 |
| Vertiv | Westerville | 1965 |
| Viacom | One Astor Plaza | December 31, 2005 |
| Viagogo | London | 2006 |
| Viasat | Carlsbad | 1986 |
| Vic Firth Company | Boston | 1963 |
| Vice Media Group | Williamsburg | 1994 |
| Vicks | Cincinnati | 1890 |
| Victoria's Secret Fashion Show | — | 1995 |
| Village Roadshow Pictures | Los Angeles | 1986 |
| Visteon | Van Buren Charter Township | 2000 |
| Vivendi Games | Los Angeles | February 21, 1996 |
| Volcom | Costa Mesa | 1991 |
| Vonage | Holmdel Township | 2001 |
| Vyond | San Mateo | November 1, 2007 |
| Waco | Troy | 1919 |
| Walt Disney Imagineering | Glendale | 1952 |
| Waltham Watch Company | Waltham, Amsterdam | 1850 |
| Warner Bros. Cartoons | Burbank, Los Angeles | November 10, 1926 |
| Warner Bros. Discovery | New York City | April 8, 2022 |
| Warner Bros. Records Inc. | New York City | March 19, 1958 |
| Warrior Sports | Warren | 1992 |
| Waste Management, Inc | Houston | 1968 |
| Waterman | Paris | 1883 |
| Waters Corporation | Milford | 1958 |
| Webster Bank | Stamford | 1935 |
| Weitek | San Jose | 1981 |
| Western Design Center | Mesa | 1978 |
| Western Electric | New York City | 1869 |
| Western Pacific Railroad | San Francisco | 1916 |
| Western Union | Denver | April 1856 |
| Westinghouse Electric Company | Cranberry Township | 1999 |
| Westwood Studios | Las Vegas | 1992 |
| Weyerhaeuser | Seattle, Federal Way | 1900 |
| WHOOP | Boston | — |
| William B. Eerdmans Publishing Company | Grand Rapids | 1911 |
| Willys | Toledo | 1908 |
| Wilson Sporting Goods | Chicago | 1913 |
| Wingstop | Dallas | 1994 |
| WiTricity | Watertown | 2007 |
| WME Group | Beverly Hills | 1898 |