| Smithfield Foods | Smithfield | 1936 |
| Sonos | Santa Barbara | 2002 |
| Sony Corporation of America | 550 Madison Avenue, New York City | 1960 |
| Sony Imagesoft | Los Angeles | 1989 |
| Sony Music | New York City | January 1, 2009 |
| Southern Company | Atlanta | 1945 |
| Southwest Airlines | Dallas | 1967 |
| Soylent | Los Angeles | 2013 |
| SpaceXAI | San Francisco Bay Area | March 9, 2023 |
| Specialized Bicycle Components | Morgan Hill | 1974 |
| Spector | Saugerties | 1976 |
| Springfield Armory | Geneseo | 1974 |
| Sprint Corporation | Overland Park | 1899 |
| Sprouts Farmers Market | Phoenix | July 2002 |
| SRI International | Menlo Park | 1946 |
| Stage 6 Films | Culver City | 2007 |
| Standard Oil of Ohio | Cleveland | 1911 |
| Staples Inc. | Framingham | 1986 |
| Stellantis North America | Chrysler Headquarters and Technology Center | April 28, 2009 |
| Strategic Simulations | Sunnyvale | 1979 |
| Strategy | Tysons | 1989 |
| Studebaker | South Bend | 1852 |
| StumbleUpon | San Francisco | 2001 |
| Substack | — | November 29, 2017 |
| SugarCRM | Cupertino | 2004 |
| Sun Microsystems | Santa Clara | February 24, 1982 |
| Supreme | New York City | April 1994 |
| SureFire | Fountain Valley | 1979 |
| SurveyMonkey | San Mateo | 1999 |
| Swift Engineering | San Clemente | 1983 |
| T. Rowe Price | Baltimore | 1937 |
| Tandem Computers | Cupertino | 1974 |
| TASCAM | Tokyo | 1971 |
| TaylorMade Golf Company | Carlsbad | 1979 |
| Tazo | Portland | 1994 |
| TBWA Worldwide | New York City | 1970 |
| TD Ameritrade | Omaha | 1971 |
| Teledyne Technologies | Thousand Oaks | 1960 |
| Tennessee Valley Authority | Knoxville | 1933 |
| Tesla Energy | Fremont | — |
| Tesoro Corporation | — | 1968 |
| The Athletic | San Francisco | January 2016 |
| The Atlantic | Washington, D.C. | 1857 |
| The Bank of New York Mellon | New York City | 2007 |
| The Cigna Group | Bloomfield | 1982 |
| The Hershey Company | Hershey | 1894 |
| The Hertz Corporation | Estero | 1918 |
| The Home Depot | Cobb County | 1978 |