| 2K | video game publisher, video game developer | Novato | 2005 |
| Activision | video game publisher, video game developer, subsidiary company | Santa Monica | October 1, 1979 |
| Adscape | business | San Francisco | 2006 |
| Airtight Games | video game developer | Redmond | 2004 |
| Amaze Entertainment | video game developer, business | Kirkland | 1997 |
| Annapurna Interactive | video game publisher, company | Los Angeles | December 1, 2016 |
| ArenaNet | video game developer, business, enterprise | Bellevue | 2000 |
| Aspyr | video game publisher, video game developer | Austin | 1996 |
| Atari Games | video game publisher, video game developer | Milpitas | July 1984 |
| Atari, Inc. | video game publisher, video game developer | New York City | February 1993 |
| Atari, Inc. | video game publisher | New York City | February 1993 |
| Bethesda Game Studios | video game developer, subsidiary company | Rockville | 2001 |
| Big Huge Games | video game developer | Timonium | February 2000 |
| Black Isle Studios | video game developer | Orange County | 1996 |
| Blizzard North | video game developer | San Mateo | 1993 |
| Bluepoint Games | video game developer | Austin | March 9, 2006 |
| Cinemaware | video game publisher, video game developer | Burlingame | 1986 |
| Coleco | brand, business | West Hartford | 1932 |
| Cyan Worlds | privately held company, video game developer, business | Wilmington, Mead | 1987 |
| Deck Nine | video game developer | Louisville | 1997 |
| Digital Anvil | video game developer | Austin | 1996 |
| EA Sports | business | Burnaby | 1991 |
| Exidy | business | Sunnyvale | 1974 |
| Firaxis Games | video game developer | Sparks | 1996 |
| Flagship Studios | video game developer | San Francisco | 2003 |
| GameTek | video game publisher, business | North Miami Beach | 1987 |
| Giant Sparrow | video game developer, business, enterprise | Santa Monica | March 22, 2009 |
| Glu Mobile | video game publisher, video game developer, business, enterprise, public company | San Francisco | 2005 |
| Gray Matter Interactive | video game developer | Los Angeles | 1994 |
| Gremlin Industries | business | San Diego | 1973 |
| Halo Studios | video game developer | Redmond | 2009 |
| High Moon Studios | video game developer | San Diego | 2001 |
| Humble Bundle, Inc. | video game publisher, digital book and audiobook distribution platform, digital distribution platform | San Francisco | March 1, 2010 |
| Imagic | video game publisher, video game developer | Los Gatos | 1981 |
| Impressions Games | video game developer | Cambridge | 1989 |
| Infinity Ward | video game developer | Woodland Hills | 2002 |
| Infocom | video game publisher, video game developer, business | Cambridge | June 22, 1979 |
| Insomniac Games | video game publisher, video game developer | Burbank | February 28, 1994 |
| Iron Lore Entertainment | video game developer | Boston | October 2000 |
| Jakks Pacific | business, public company | Malibu | 1995 |
| LCG Entertainment, Inc. | video game publisher, video game developer | Malibu | December 27, 2018 |
| Loki Entertainment | video game developer | Tustin | November 9, 1998 |
| MicroProse | video game developer | Hunt Valley | 1982 |
| Mistwalker | video game developer, business, enterprise | Tokyo, Japan, Honolulu | 2004 |
| Monolith Productions | publishing house, video game developer | Kirkland | October 25, 1994 |
| Mythic Entertainment | video game developer | Fairfax | 1995 |
| Nerve Software | video game developer | Richardson | 1999 |
| NetherRealm Studios | video game developer | Chicago | 2010 |