| Organon & Co. | Oss | 1923 |
| Otis Worldwide Corporation | Farmington | 1853 |
| Ovintiv | Denver | 2020 |
| PACCAR | Bellevue | 1905 |
| Palantir Technologies | Miami | 2003 |
| Panera Bread | Sunset Hills | 1987 |
| Papa John's | Louisville | October 2, 1984 |
| Peabody Energy | St. Louis | 1883 |
| Pegasystems | Cambridge | 1983 |
| Pilgrim's Corp | Greeley | 1946 |
| Pitney Bowes | Stamford | 1920 |
| PNC Financial Services | One PNC Plaza | 1982 |
| Polaris | Medina | 1954 |
| PPG Industries | Pittsburgh | 1883 |
| Qualcomm | San Diego | July 1985 |
| Qualtrics | Provo | 2002 |
| RadioShack | Fort Worth | 1921 |
| Rambus | Sunnyvale | 1990 |
| Razer Inc. | George Town, Singapore, Carlsbad, Irvine, San Francisco | 1998 |
| Realty Income Corporation | San Diego | 1969 |
| Red Hat | Raleigh | March 27, 1993 |
| Red Robin | Greenwood Village | 1940 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Republic Airways Holdings | Indianapolis | 1973 |
| Revlon | New York City | 1932 |
| Rivian Automotive | Detroit | June 2009 |
| Rockwell International | United States | February 1973 |
| Roku, Inc. | Los Gatos | October 2002 |
| Ross Dress for Less | Dublin | 1954 |
| RTX | Arlington County | April 3, 2020 |
| Ryder | Coral Gables | 1933 |
| S&P Global | Rockefeller Center, New York City | — |
| Safeway | Pleasanton | 1915 |
| Salesforce | Salesforce Tower, San Francisco | February 3, 1999 |
| Sanmina Corporation | San Jose | 1980 |
| Scholastic Corporation | New York City, Scholastic Building | 1920 |
| Sears | Hoffman Estates | 1892 |
| Semrush | Boston | August 3, 2008 |
| Sigma-Aldrich | St. Louis | 1976 |
| Similarweb | Givatayim | 2007 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Six Flags | Arlington | 1961 |
| Skechers | Manhattan Beach | 1992 |
| Skullcandy | Park City | 2003 |
| Slack Technologies | San Francisco | 2009 |
| Smith & Wesson | Springfield | 1852 |
| Smithfield Foods | Smithfield | 1936 |
| Sonos | Santa Barbara | 2002 |