| Datadog | New York City | 2010 |
| Del Taco | Lake Forest | 1965 |
| Dell | Round Rock | September 7, 2016 |
| Dell EMC | Hopkinton | August 1979 |
| Dell Technologies | Round Rock | September 7, 2016 |
| Denny's | Spartanburg | 1953 |
| Devon Energy | Oklahoma City | 1971 |
| Dick's Sporting Goods | Coraopolis | 1948 |
| DigitalBridge | Boca Raton | 1991 |
| DigitalOcean | New York City | August 2011 |
| Discover Financial | Wilmington, Riverwoods | 1960 |
| Discovery, Inc. | New York City | 1982 |
| Dolby | San Francisco | 1965 |
| Dollar General | Goodlettsville | 1939 |
| Dominion Energy | Richmond | 1983 |
| Dover Publications | New York, Mineola | 1941 |
| Dow Inc. | Midland | January 1, 2019 |
| DreamWorks Animation | Glendale | 1994 |
| Dunkin' Brands | Canton | 1950 |
| EarthLink | Atlanta, Pasadena, Atwater Village | 1994 |
| Eastman Chemical Company | Kingsport | 1920 |
| Eaton Corporation | Cleveland | 1911 |
| Ecolab | Saint Paul | 1923 |
| Enterprise Products | Houston | 1968 |
| Estée Lauder Companies | Neuilly-sur-Seine, New York City | 1946 |
| Euronet Worldwide | Leawood | 1994 |
| Exelon | Chicago | 2000 |
| Expedia Group | Seattle | October 22, 1996 |
| Exxon | Las Colinas | January 1, 1973 |
| ExxonMobil | Spring | August 5, 1882 |
| F. W. Woolworth Company | New York City | 1878 |
| FactSet | Norwalk | 1978 |
| FEI Company | Hillsboro | 1971 |
| First Citizens BancShares | Raleigh | August 7, 1986 |
| First Solar | Tempe | 1999 |
| FirstEnergy | Akron | 1997 |
| Fiserv | Brookfield | 1984 |
| Fluor Corporation | Irving | 1890 |
| FMC Corporation | BNY Mellon Center | 1883 |
| FMC Technologies | Houston | 2000 |
| Ford Motor Company | Dearborn | June 16, 1903 |
| Fortinet | Sunnyvale | 2000 |
| Fortress Investment Group | 1345 Avenue of the Americas | 1998 |
| Fox Corporation | New York City | 2019 |
| Franklin Templeton Investments | San Mateo | 1947 |
| Freeport-McMoRan | Phoenix | 1912 |
| GameStop | Grapevine | August 20, 1980 |
| General American Transportation Corporation | Chicago | 1933 |