| Peavey Electronics | Meridian | 1965 |
| Perforce Zend | Minneapolis | 1999 |
| Pioneer Hi-Bred | Johnston | 1926 |
| Pitney Bowes | Stamford | 1920 |
| Playboy Enterprises | Los Angeles | 1953 |
| PNC Financial Services | One PNC Plaza | 1982 |
| Polaris | Medina | 1954 |
| PPG Industries | Pittsburgh | 1883 |
| Praxair | Danbury | 1907 |
| Precision Manuals Development Group | Alexandria | 1997 |
| Providence Equity Partners | 50 Kennedy Plaza | 1989 |
| Quaker Oats Company | Chicago | 1877 |
| R. J. Reynolds Tobacco Company | Winston-Salem | 1874 |
| Rambus | Sunnyvale | 1990 |
| Re-Logic | Floyds Knobs | 2011 |
| RE/MAX | Denver | 1973 |
| RealNetworks | Seattle | 1993 |
| Red Digital Cinema Camera Company | Lake Forest | 2005 |
| Red Hat | Raleigh | March 27, 1993 |
| Reebok | Boston | 1895 |
| Remington Arms | Madison | 1816 |
| Remote Control Productions | Santa Monica | 1989 |
| Revlon | New York City | 1932 |
| Rivian Automotive | Detroit | June 2009 |
| Rohm and Haas | Philadelphia | September 1, 1909 |
| Roku, Inc. | Los Gatos | October 2002 |
| Ross Dress for Less | Dublin | 1954 |
| Rough Draft Studios | Glendale | 1990 |
| RSA | Bedford | 1986 |
| S&P Global | Rockefeller Center, New York City | — |
| Safeway | Pleasanton | 1915 |
| Salesforce | Salesforce Tower, San Francisco | February 3, 1999 |
| Scripps-Booth | Detroit | 1913 |
| Shimmer Women Athletes | Illinois, Chicago, Berwyn | November 6, 2005 |
| Shure | Niles | 1925 |
| Sigma-Aldrich | St. Louis | 1976 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| Six Flags | Arlington | 1961 |
| Skechers | Manhattan Beach | 1992 |
| Smith & Wesson | Springfield | 1852 |
| Smithfield Foods | Smithfield | 1936 |
| Sonos | Santa Barbara | 2002 |
| SoundHound | Santa Clara | September 2005 |
| Southern Company | Atlanta | 1945 |
| Specialized Bicycle Components | Morgan Hill | 1974 |
| Splunk Inc. | San Francisco | 2004 |
| Sprint Corporation | Overland Park | 1899 |
| Staples Inc. | Framingham | 1986 |