| American Axle | business, enterprise, public company | Detroit | 1994 |
| American Motors Corporation | automobile manufacturer | Kenosha | 1954 |
| AutoZone | car parts shop chain, public company | Memphis | 1979 |
| Baker Motor Vehicle | business, automobile manufacturer | Cleveland | 1899 |
| BorgWarner | business, enterprise, public company | Auburn Hills | 1880 |
| Canoo | business, automobile manufacturer, public company | Torrance | 2017 |
| Carroll Shelby International | automobile manufacturer | Enterprise | August 17, 1962 |
| Cartercar | business, automobile manufacturer | Pontiac | 1905 |
| Checker Motors Corporation | automobile manufacturer | Kalamazoo | 1922 |
| Cord Automobile | business | United States | 1929 |
| Dana Corporation | business, public company | Toledo | 1904 |
| DeLorean Motor Company | automobile manufacturer | Detroit | October 24, 1975 |
| Detroit Electric Car Company | business, automobile manufacturer | Detroit | 1907 |
| Diamond-Star Motors | business, automobile manufacturer | — | October 1985 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| Eagle | car brand, automobile manufacturer | — | 1987 |
| Faraday Future | automobile manufacturer | Gardena | 2014 |
| Ford Motor Company | holding company, organization, business, automobile manufacturer, public company | Dearborn | June 16, 1903 |
| Freightliner Trucks | truck manufacturer, trademark | Portland | 1939 |
| Global Electric Motorcars | business, automobile manufacturer | Fargo | 1992 |
| Henry Ford Company | business, automobile manufacturer | Detroit | 1901 |
| Hudson Motor Car Company | business, automobile manufacturer | Detroit | 1909 |
| Hupmobile | business, automobile manufacturer | Detroit | 1909 |
| International | commercial vehicle manufacturer, enterprise, public company | Lisle | 1986 |
| K-R-I-T Motor Car Company | business | Detroit | 1909 |
| Kaiser Jeep | business, automobile manufacturer | Toledo | 1953 |
| Kaiser Motors | automobile manufacturer | Ypsilanti | 1945 |
| LaSalle | automobile manufacturer | Detroit | 1927 |
| Lincoln Motor Company | car brand, automobile manufacturer, public company | Dearborn | 1917 |
| PACCAR | commercial vehicle manufacturer, enterprise, public company | Bellevue | 1905 |
| Panoz Auto Development | business, enterprise, automobile manufacturer | Hoschton | 1989 |
| Peerless | business, defunct organization, automobile manufacturer | Cleveland | 1900 |
| Polaris | motorcycle manufacturer, enterprise, automobile manufacturer, public company | Medina | 1954 |
| Pope Manufacturing Company | automobile manufacturer | Hartford | 1876 |
| Ram Trucks | car brand, division, automobile manufacturer | Auburn Hills | 2010 |
| Rickenbacker | automobile manufacturer | Detroit | 1921 |
| Rivian Automotive | business, enterprise, automobile manufacturer, public company | Detroit | June 2009 |
| SAE International | engineering society, regulatory college, standards organization, business, company, academic publisher | Warrendale | 1905 |
| Scripps-Booth | business, enterprise, automobile manufacturer | Detroit | 1913 |
| Scuderia Cameron Glickenhaus | automobile manufacturer | Sleepy Hollow | 2004 |
| Stanley Motor Carriage Company | automobile manufacturer | Newton | 1902 |
| Stellantis North America | business, enterprise, automobile manufacturer | Chrysler Headquarters and Technology Center | April 28, 2009 |
| Studebaker | business, automobile manufacturer | South Bend | 1852 |
| Thomas Built Buses | automobile manufacturer | High Point | 1972 |
| Willys | business, automobile manufacturer | Toledo | 1908 |