| Salesforce | software company, technology company, software developer, business, enterprise, public company | February 3, 1999 |
| San Francisco Museum of Modern Art | nonprofit organization, art museum, publishing house, museum, museum of modern art | 1935 |
| San Francisco Opera | nonprofit organization, opera company | 1923 |
| Scale AI | technology company | 2016 |
| Scribd | online service, organization, business | March 2006 |
| Shaba Games | business | 1997 |
| Skydance Direct-to-Consumer | media company | April 12, 2007 |
| Slack Technologies | business, public company | 2009 |
| Splunk Inc. | software company, enterprise, public company | 2004 |
| StumbleUpon | website, business | 2001 |
| The Athletic | online newspaper, podcast network, business, sports journalism | January 2016 |
| The Learning Company | video game developer | 1980 |
| Twilio | website, business, company, public company | 2008 |
| Uber | food delivery, platform company, Internet booking engine, ridesharing company, organization, business, data controller, online taxi service, enterprise, software, public company | March 2009 |
| Udemy | website, education company | 2010 |
| Union Iron Works | business | 1849 |
| University of San Francisco | publishing house, private not-for-profit educational institution, university, open-access publisher | 1855 |
| Vicarious | privately held company | 2010 |
| Western Pacific Railroad | business, transport company | 1916 |
| WordPress.com | domain name registrar, content management system, website builder, nonprofit organization, business, web hosting service, Fediverse app | 2005 |