| Carnegie Mellon University | research university, private not-for-profit educational institution, private university | 1900 |
| Carnegie Steel Company | enterprise | 1892 |
| Consol Energy | business, enterprise, public company | 1991 |
| H. J. Heinz Company | food manufacturer, commercial organization | 1869 |
| Kraft Heinz | organization, business, enterprise, public company | 2015 |
| MSA Safety | business, public company | 1914 |
| PPG Industries | organization, business, enterprise, public company | 1883 |