| Academy of Natural Sciences of Drexel University | nonprofit organization, natural history museum, academy of sciences, learned society | 1812 |
| American Bible Society | Bible society, nonprofit organization | May 11, 1816 |
| American Line | transport company | 1871 |
| Bare Knuckle Fighting Championship | business | 2018 |
| Budd Company | business, aerospace manufacturer | 1912 |
| Chikara | business, professional wrestling promotion | 2002 |
| Clarivate | public company | October 3, 2016 |
| Comcast | telecommunications company, business, enterprise, public company | June 28, 1963 |
| Conrail | railway company | April 1, 1976 |
| Evolve | business | 2009 |
| Extreme Championship Wrestling | media franchise, business | April 25, 1992 |
| Free Library of Philadelphia | nonprofit organization, library network, public library | 1891 |
| Institute for Scientific Information | business, enterprise | 1960 |
| Lubin Manufacturing Company | film production company | 1902 |
| Penn Central Transportation Company | railway company | 1968 |
| Philco | business | 1892 |
| Piasecki Helicopter Corporation | former entity, aerospace manufacturer | 1940 |
| Rohm and Haas | business, enterprise | September 1, 1909 |
| The University of the Arts | private not-for-profit educational institution, university | 1987 |
| The Wharton School | business school, private university | 1881 |