| American Axle | business, enterprise, public company | 1994 |
| DeLorean Motor Company | automobile manufacturer | October 24, 1975 |
| Detroit Electric Car Company | business, automobile manufacturer | 1907 |
| Henry Ford Company | business, automobile manufacturer | 1901 |
| Hudson Motor Car Company | business, automobile manufacturer | 1909 |
| Hupmobile | business, automobile manufacturer | 1909 |
| K-R-I-T Motor Car Company | business | 1909 |
| LaSalle | automobile manufacturer | 1927 |
| Rickenbacker | automobile manufacturer | 1921 |
| Rivian Automotive | business, enterprise, automobile manufacturer, public company | June 2009 |
| Scripps-Booth | business, enterprise, automobile manufacturer | 1913 |
| Studebaker-Packard Corporation | automobile manufacturer | 1954 |
| Wayne State University | public educational institution of the United States, public research university | 1868 |